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KMID : 1037020160050010022
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Medical Lasers; Engineering, Basic Research, and Clinical Application
2016 Volume.5 No. 1 p.22 ~ p.28
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Therapeutic Efficacy of 1,927-nm Fractionated Thulium Laser Energy and Polydeoxyribonucleotide on Pattern Hair Loss
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Cho Sung-Bin
Zhenlong Zheng
Kang Jin-Soo
Kim Hee-Su
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Abstract
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Background and Objectives: Intra-perifollicular polydeoxyribonucleotide (PDRN) injections result in clinical improvements in hair thickness and density in patients with pattern hair loss (PHL). The objective of this study is to evaluate the efficacy of combined treatment with a 1,927-nm fractionated thulium laser and PDRN injections for treatment of PHL.
Materials and Methods: We compared clinical outcomes in eight PHL patients treated with 12 sessions of combined treatment with thulium laser and PDRN injections to those in another eight PHL patients treated with 12 sessions of mesotherapy and PDRN injections.
Results: One week after the final treatment session, patients treated with the thulium laser and PDRN showed clinical improvements in mean hair counts (20.4 ± 15.7%; p=0.005) and mean hair thickness (53.1 ± 31.1%; p<0.001), compared to baseline values. Patients treated with mesotherapy and PDRN also showed clinical improvements in mean hair counts (9.7 ± 7.4%; p=0.007) and mean hair thickness (16.1 ± 25%; p>0.05). Further statistical analysis showed that combined treatment with the thulium laser and PDRN injections resulted in greater improvement in hair thickness (p=0.029) than combined application of mesotherapy and PDRN, but not in hair counts (p>0.05).
Conclusion: Use of thulium laser energy in combination with PDRN injections for treatment of PHL results in remarkable improvements in hair thickness and density.
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KEYWORD
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Pattern hair loss, Thulium laser, Polydeoxyribonucleotide, Mesotherapy
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